JPH0440347B2 - - Google Patents

Info

Publication number
JPH0440347B2
JPH0440347B2 JP56086555A JP8655581A JPH0440347B2 JP H0440347 B2 JPH0440347 B2 JP H0440347B2 JP 56086555 A JP56086555 A JP 56086555A JP 8655581 A JP8655581 A JP 8655581A JP H0440347 B2 JPH0440347 B2 JP H0440347B2
Authority
JP
Japan
Prior art keywords
group
dimethylpyrimidine
crystals
cyclopenta
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP56086555A
Other languages
English (en)
Japanese (ja)
Other versions
JPS57203072A (en
Inventor
Toshiharu Kamioka
Isao Nakayama
Takeo Pponda
Takashi Furubayashi
Tokio Obata
Katsutoshi Fujii
Mikio Kojima
Juji Akyoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Ube Corp
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Priority to JP56086555A priority Critical patent/JPS57203072A/ja
Priority to PH27381A priority patent/PH20130A/en
Priority to US06/384,416 priority patent/US4450162A/en
Priority to EP82302870A priority patent/EP0067630B1/en
Priority to DE8282302870T priority patent/DE3263653D1/de
Priority to ES512880A priority patent/ES8307760A1/es
Priority to KR8202513A priority patent/KR880002234B1/ko
Priority to ZA823917A priority patent/ZA823917B/xx
Priority to CA000404529A priority patent/CA1169861A/en
Priority to FI821990A priority patent/FI77454C/fi
Publication of JPS57203072A publication Critical patent/JPS57203072A/ja
Publication of JPH0440347B2 publication Critical patent/JPH0440347B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP56086555A 1981-06-05 1981-06-05 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient Granted JPS57203072A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP56086555A JPS57203072A (en) 1981-06-05 1981-06-05 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient
PH27381A PH20130A (en) 1981-06-05 1982-05-31 Pyrimidine derivatives,a process for preparing them and pharmaceutical composition containing them
US06/384,416 US4450162A (en) 1981-06-05 1982-06-02 Pyrimidine derivatives and a pharmaceutical composition containing them
EP82302870A EP0067630B1 (en) 1981-06-05 1982-06-03 Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them
DE8282302870T DE3263653D1 (en) 1981-06-05 1982-06-03 Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them
ES512880A ES8307760A1 (es) 1981-06-05 1982-06-04 Un procedimiento para la preparacion de derivados de 4-anilino-pirimidina.
KR8202513A KR880002234B1 (ko) 1981-06-05 1982-06-04 4-아닐리노피리미딘 유도체의 제조방법
ZA823917A ZA823917B (en) 1981-06-05 1982-06-04 Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them
CA000404529A CA1169861A (en) 1981-06-05 1982-06-04 Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them
FI821990A FI77454C (fi) 1981-06-05 1982-06-04 Foerfarande foer framstaellning av som laekemedel anvaendbara 4-anilino-pyrimidinderivat.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56086555A JPS57203072A (en) 1981-06-05 1981-06-05 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient

Publications (2)

Publication Number Publication Date
JPS57203072A JPS57203072A (en) 1982-12-13
JPH0440347B2 true JPH0440347B2 (en]) 1992-07-02

Family

ID=13890246

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56086555A Granted JPS57203072A (en) 1981-06-05 1981-06-05 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient

Country Status (10)

Country Link
US (1) US4450162A (en])
EP (1) EP0067630B1 (en])
JP (1) JPS57203072A (en])
KR (1) KR880002234B1 (en])
CA (1) CA1169861A (en])
DE (1) DE3263653D1 (en])
ES (1) ES8307760A1 (en])
FI (1) FI77454C (en])
PH (1) PH20130A (en])
ZA (1) ZA823917B (en])

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK130584A (da) * 1983-04-08 1984-10-09 Ciba Geigy Ag N-(2-nitrophenyl)-4-amino-pyrimidin-derivater samt deres fremstilling og anvendelse som mikrobicider
PH21918A (en) * 1983-07-25 1988-04-08 Ciba Geigy Ag N-(2-nitrophenyl)-5-aminopyrimidine derivatives,the preparation and use thereof
EP0139613A1 (de) * 1983-08-29 1985-05-02 Ciba-Geigy Ag N-(2-Nitrophenyl)-4-aminopyrimidin-Derivate, deren Herstellung und Verwendung
US4725600A (en) * 1984-07-13 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
US4749704A (en) * 1985-03-07 1988-06-07 Sankyo Company Limited Cyclopenta[d]pyrimidine derivatives and use as antidepressants
DE3618353A1 (de) * 1986-05-31 1987-12-03 Hoechst Ag Schaedlingsbekaempfungsmittel auf der basis von aminopyrimidin-derivaten sowie neue aminopyrimidin-verbindungen
US5037980A (en) * 1988-04-18 1991-08-06 American Cyanamid Company Phenyl imidazo[1,2-a]pyrimidines
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
US5234936A (en) * 1991-10-24 1993-08-10 American Home Products Corporation Pyrimidocycloalkanes as a ii antagonists
DE69329067T2 (de) * 1992-10-05 2001-05-10 Ube Industries, Ltd. Pyridmidin-derivate
ES2361146T3 (es) * 1998-03-27 2011-06-14 Janssen Pharmaceutica Nv Derivados de la piramidina inhibitatoria de vih.
ID26291A (id) * 1998-03-27 2000-12-14 Janssen Pharmaceutica Nv Turunan-turunan pirimidina penghambat hiv
BRPI0014271B1 (pt) 1999-09-24 2021-06-22 Janssen Pharmaceutica N.V. Partícula consistindo em uma dispersão de sólidos, uso da dita partícula, dispersão de sólidos, forma de dosagem farmacêutica, bem como processos de preparação de dita partícula, dispersão e forma de dosagem
JP2007501821A (ja) * 2003-08-12 2007-02-01 エフ．ホフマン−ラ　ロシュ　アーゲー Ｃｆｒアンタゴニストとしてのテトラヒドロキナゾリン誘導体
RU2007122485A (ru) 2004-11-17 2008-12-27 Мийкана Терапьютикс Ингибиторы киназы
ES2535854T3 (es) * 2005-09-30 2015-05-18 Miikana Therapeutics, Inc. Compuestos de pirazol sustituidos
JP2010529193A (ja) * 2007-06-11 2010-08-26 ミイカナ セラピューティクス インコーポレイテッド 置換ピラゾール化合物
US8946239B2 (en) 2008-07-10 2015-02-03 Duquesne University Of The Holy Spirit Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
JP6532887B2 (ja) * 2014-04-03 2019-06-19 デュケイン ユニバーシティー オブ ザ ホリー スピリット 抗有糸分裂活性および／または抗腫瘍活性を有する置換シクロペンタピリミジン二環式化合物およびその使用方法
GB2578973B (en) * 2015-04-17 2020-08-26 Univ Holy Ghost Duquesne Pyrrolopyrimidines as antitumor agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2719846A (en) * 1954-05-06 1955-10-04 Searle & Co 4[n-(beta-diethylaminoethyl) anilino]-pyrimidine and acid addition salts thereof
US3321478A (en) * 1963-09-20 1967-05-23 American Cyanamid Co Aminoethoxyphenyl amine, ether, and sulfide derivatives of pyrimidine
FR2190818B1 (en]) * 1972-06-28 1975-03-07 Roussel Uclaf
CH593266A5 (en]) * 1973-09-20 1977-11-30 Delalande Sa
DE2626495A1 (de) * 1976-06-12 1977-12-29 Bayer Ag Quartaere reaktivverbindungen

Also Published As

Publication number Publication date
KR840000508A (ko) 1984-02-22
EP0067630B1 (en) 1985-05-08
US4450162A (en) 1984-05-22
DE3263653D1 (en) 1985-06-13
ES512880A0 (es) 1983-08-01
KR880002234B1 (ko) 1988-10-20
PH20130A (en) 1986-10-02
FI77454C (fi) 1989-03-10
EP0067630A1 (en) 1982-12-22
CA1169861A (en) 1984-06-26
ZA823917B (en) 1983-04-27
JPS57203072A (en) 1982-12-13
FI821990A0 (fi) 1982-06-04
ES8307760A1 (es) 1983-08-01
FI77454B (fi) 1988-11-30

Similar Documents

Publication Publication Date Title
JPH0440347B2 (en])
US3780040A (en) 2-substituted-3,4-dihydroquinazolines
US3696197A (en) Pharmaceutical compositions containing homopyrimidazole derivatives
JPH0224821B2 (en])
IE51551B1 (en) Isoquinoline derivatives,process for their preparation and pharmaceutical formulations containing them and their use
JPS6318591B2 (en])
US20140336199A1 (en) Compounds and Pharmaceutical Compositions for Treating Disorders Associated With the 5-HT1A and 5-HT2A Receptors
JPH0747574B2 (ja) ピリジン誘導体及びそれを有効成分とする向精神剤
JPS6353162B2 (en])
JPS6365672B2 (en])
AU698673B2 (en) Heterocyclic chemistry
JPH08502057A (ja) カルモジュリン拮抗特性を有する複素環式アミン
IE49549B1 (en) Piperazine derivatives
JPS62161768A (ja) ３（２ｈ）―ピリダジノン誘導体及びこれを含む薬剤組成物
JPS62111970A (ja) 置換された３−（４−フエニル−１−ピペラジニル）アルキルキナゾリン−２，４−（１ｈ，３ｈ）ジオン類
DK158518B (da) Phenylpiperazinderivater og syreadditionssalte deraf, fremgangsmaade til fremstilling deraf samt praeparater indeholdende derivaterne
JPS62108863A (ja) ２−ピリジル酢酸誘導体、その製法およびそれを含む医薬
JPH0215547B2 (en])
JPS6117832B2 (en])
KR100408364B1 (ko) 3(2에이치)-피리다지논유도체및이들화합물을함유하는제약학적인조성물
KR100556559B1 (ko) 2-(4-(4-(4,5-디클로로-2-메틸이미다졸-1-일)부틸)-1-피페라지닐)-5-플루오로피리미딘, 이것의 제조 방법 및 이것의치료적 용도
US20040038966A1 (en) Cyclic amine derivatives and use thereof
JPS6259090B2 (en])
JPS61280486A (ja) Ｎ−フエニル−４−フエニル−１−ピペラジンカルボキシアミジン類
JPH0314830B2 (en])